Ink Spots - If I Didn't Care

Here are the Lyrics:

If I didn't care more than words can say 

If I didn't care would I feel this way?

 If this isn't love then why do I thrill? 

And what makes my head go 'round and 'round 

While my heart stands still? 

If I didn't care would it be the same? 

Would my ev'ry prayer begin and end with just your name? 

And would I be sure that this is love beyond compare? 

Would all this be true if I didn't care for you? 

 MONOLOGUE: 

If I didn't care honey child, mo' than words can say. 

If I didn't
care baby, would I feel this way? 

Darlin' if this isn't love, then why do I thrill so
much? 

What is it that makes my head go 'round and 'round while my heart just stands
still so much ? 

If I didn't care would it be the same? 

Would my ev'ry prayer begin and end with just your name?

And would I be sure that this is love beyond compare?

Would all this be true if I didn't care for you?

Link: https://youtu.be/rvwfLe6sLis

New cartoon series aims to simplify understanding of addiction

In Episode 1- “The Hijacker,” learn about how substance use disorders (SUDs) affect tissue function in two main parts of the brain: 

i - the limbic system (responsible for basic survival instincts) and 

ii - the prefrontal cortex (where decision-making and impulse control live). 

Substance use activates the dopamine process in the survival center much more powerfully than natural rewards like food or sex. 

When repeated it can hijack the brain, making it think that the substance is the most important thing for survival.

Over time, more and more of the substance is needed to activate the same level of reward, causing the brain’s circuits to become increasingly imbalanced
--eroding a person’s self-control and ability to make sound decisions, 
while producing intense impulses to seek and use the substance. 

This is what it means when scientists say that addiction is a brain disease. 

The good news – SUDs are preventable and treatable, and brain scans show that once an individual is in recovery, brain tissue can get better. 

  https://www.addictionpolicy.org/addic...

“ADDICTION” is an animated video series that turns the science on substance use disorder (SUD) and addiction into stories that stick.

 Want to learn more? Need help? Worried about a loved one?

Visit the ARC 

www.addictionresourcecenter.org 

Animated by Patrick Smith
Produced by the Addiction Policy Forum
Written by Maureen Boyle, PhD, Braeden Kelly, Jessica Hulsey Nickel, and Lisbet Hope Portman.

Thanks to the National Institute on Drug Abuse (NIDA) for the science highlighted. https://www.drugabuse.gov/





Link: https://youtu.be/MbOAKmzKmJo

Breaking the Cycle of Addiction, With Hallucinogens

Breaking the Cycle of Addiction, With Hallucinogens 

 https://trib.al/yMrrR3j 

  pic.twitter.com/jDnngrxM80

Understanding Alcohol Abuse

Link: https://drugabuse.com/library/the-effects-of-alcohol-use/

The Effects of Alcohol Use

Reviewed By Eric Patterson, MSCP, NCC, LPC

1. Table of Contents
2. Understanding Alcohol Abuse
3. Short-term Effects of Alcohol
4. Side Effects
5. Long-Term Effects of Alcohol
6. Alcohol Dependence
7. Am I Addicted to Alcohol?
8. Withdrawal Treatment

Understanding Alcohol Abuse

Enjoying alcohol in moderation is not just "not bad" for you, but it may have health benefits that could prolong your life. It is when people use alcohol as an escape route for social, personal or career pressures that abuse or alcoholism can result. Abuse of alcohol, or consumption of more alcohol than the body can handle, can lead to liver damage and other debilitating conditions.
Alcohol abuse can also lead to alcoholism--diagnosed as alcohol use disorder in the latest Diagnostic and Statistical Manual (DSM-5)--or alcohol addiction, in which a person becomes physically and psychologically dependent on alcohol to the point that he or she cannot function without it. Alcohol abuse and addiction can also lead to destructive behavior such as driving under the influence of alcohol and domestic violence.
According to the US Substance Abuse and Mental Health Services Administration, in 2013, 18.0 million people age 12 years or older in the US needed treatment for alcohol use (6.9% of Americans age 12 or older).

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Short-term Effects of Alcohol

Most adults will experience no detrimental effects from one or two servings of alcohol a day. A serving is a four-ounce glass of wine, a 12-ounce can of beer or a 1.5-ounce shot of a distilled spirit. This level of consumption may even decrease the risk of cardiovascular disease and dementia.
Short-term effects of doses of alcohol above that safe level, which differs for people depending upon weight and whether they consume on an empty stomach, begin with relaxation and reduced inhibitions. While these effects[/link] may be pleasant, they then progress to lowered concentration, lowered reflex and response time and poor coordination, all of which result from a slowdown in the activity of the brain.

Short-Term Effects of Alcohol Use

• Slurring of speech.
• Drowsiness.
• Emotional changes.
• Sleep disruption.
• Lowering of body temperature.

Symptoms of Excess Alcohol Intake

• Nausea and vomiting.
• Loss of bladder and bowel control.
• Blackouts, in which a drinker does not remember what happened while he or she was drinking.
• Temporary loss of consciousness.
• Coma and death.

Any short-term effect of alcohol can be amplified when alcohol is consumed in conjunction with other mind-altering substances including both legal and illegal drugs. People who are using medication for pain or treatment of psychological conditions should not even consume alcohol in moderation without consulting their doctors.

---

Video: Causes of Alcoholism

Credit: Howcast

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Side Effects

The side effects of alcohol include the hangover, in which headaches, nausea, and vomiting continue after a drinker is no longer actually intoxicated or experiencing the alcohol high.
Weight gain and high blood pressure can result from repeated overconsumption of alcohol, and long-term overconsumption of alcohol can raise the risk for:

• Depression.
• Liver damage.
• Cancer.
• Depression of the immune system.
• Reduced sexual performance.

Alcohol use can also have serious consequences for expecting and breastfeeding mothers and their babies, including fetal alcohol syndrome.

---

Long-Term Effects of Alcohol

Long-term overconsumption of alcohol causes death of brain cells, which can lead to brain disorders as well as a lowered level of mental or physical function.
Liver damage from alcohol can result in cirrhosis, a severe medical condition that can require a liver transplant to treat.
Long-term overconsumption of alcohol can cause pancreatitis, a very dangerous inflammation of the pancreas, and it can also cause nerve damage.
Tolerance, a long-term effect of alcohol in which the body becomes accustomed to higher and higher doses of alcohol after a long period of overconsumption. This makes it possible for long-term drinkers to consume amounts of alcohol that are dangerous without experiencing short-term effects that might otherwise convince them to stop. Tolerance can lead to dependence and then to addiction or alcoholism in some individuals.

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Alcohol Dependence

Alcohol dependence, or alcoholism, occurs when the body cannot function without alcohol. Alcohol affects certain neurotransmitters in the brain. When the brain becomes accustomed to the way that alcohol affects these brain chemicals, it can no longer send proper signals to the rest of the body without the presence of alcohol.
Once someone has developed a dependence on alcohol, he or she will continue to drink regardless of any serious physical symptoms caused by alcohol. In addition, a person who has developed alcohol dependence will continue to drink even if he or she suffers social or personal circumstances such as the loss of a job or career, breakup of personal relationships, or arrests for behavior related to alcohol consumption.

---

Am I Addicted to Alcohol?

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Withdrawal Treatment

Alcohol dependence is a physical disorder that requires medical treatment, as attempts to withdraw alcohol from a dependent patient will lead to unpleasant and even potentially dangerous withdrawal symptoms. Medical treatment for alcohol dependence is known as detoxification, or detox, and it is followed by inpatient or outpatient rehabilitation treatment and therapy that helps patients avoid future alcohol abuse.

 

 

 

Alcohol Addiction Most Treated of all the Substances

Ethanol (alcohol) is abused at a higher rate than any other drug among treatment program attendees, as reported by a 2017 survey from Recovery Brands.
Nearly 70% of people who took the survey went to treatment to get help with a drinking problem, and a surprising 52.87% of those who responded reported seeking treatment for a problem with alcohol more than any other substance. No matter how many substances of abuse there are, the one that causes the most extensive harm is ethanol.
If you or someone you love is addicted to alcohol, you are not alone, and there is help available.

In a residential rehab center, intensive counseling and therapy that helps patients find positive ways of dealing with the stress and pressures that led them to abuse alcohol begins as soon as the acute detoxification process is over.
Residential treatment programs lasting from 30 days including detox to 90 days and beyond are available at rehab centers that are located in pleasant surroundings where patients can focus solely on recovery. Once the inpatient phase of treatment is complete, counselors at these centers encourage patients to continue treatment with outpatient addiction professionals as well as by joining self-help support groups such as Alcoholics Anonymous.

 

 

 

 

 

Overcome Your Addiction

Get Help Now.  

 

You're Ready to Escape Addiction

How Alcohol Abuse Affects the Brain

 

 

 

How Alcohol Abuse Affects the Brain

Wednesday, 02 August 2017 06:00  by Taylor S.

 

 

 

When most people think of health, they think of the condition of their body and its organs. Alcohol abuse causes damage to a number of organs and systems in the body, and these conditions are well documented. Some of the more notable effects of alcohol on the body include a breakdown of the digestive system, tissue damage in the digestive tract, and an inability to properly absorb nutrients. The circulatory system can also be seriously affected resulting in high blood pressure, heart disease or stroke.
Alcoholism can also have more intangible effects on your life. It often damages relationships with family and friends. With an addiction, the alcohol becomes more important than anything or anyone in your life. Addiction to alcohol changes your priorities and your demeanor. Relationships are damaged when alcohol affects your behavior and comes between you and the people you love. It is impossible to build and nurture a healthy relationship and uphold your responsibilities to the people in your life while you are in the throws of addiction.

Short-Term Effects of Alcohol

Alcohol begins to affect your brain from the very first drink. The high you feel from consuming alcohol is the result of its influence on your brain chemistry. Alcohol taps into the chemical messaging system in your brain and central nervous system. It alters your perceptions by through your brain’s messaging system. Alcohol binds to receptors in your brain where your natural brain chemicals should go and hijacks the controls.
While you are actively consuming alcohol, and it is flooding your brain with impostor chemical messages, these short-term effects can be observed:

• Memory impairment - Alcohol interferes with your brain’s ability to encode information and move it between short- and long-term memory.
• Poor decision-making - When you are drunk, the part of the brain that is responsible for making decisions is impaired. This can cause you to make poor decisions, such as unsafe sex or other risky behaviors.
• Dangerous behaviors - People seem more outgoing and social when they are drinking, but this is also part of the depressant effect happening in the brain. Fear is suppressed, and behavior can range from socially brave to life-threateningly dangerous.
• Coordination impairment - An inability to walk properly is part of the poor coordination you may experience when under the influence of alcohol. It is a sign that the alcohol is depressing your central nervous system, slowing your movements, and interfering with your ability to balance. Reaction times are also slowed, which is one of many reasons why driving under the influence of alcohol is never a good idea.
• Slurred speech - Speech is a complex coordination in the brain between language abilities and muscle movement in the face and throat. When motor skills are depressed by alcohol, speech becomes affected by slurring that can become so severe, no intelligible words come out.
• Black outs - This is a sign your brain is shutting down non-essential functions to divert all available energy to basic life support.

Short-term effects of alcohol seem to resolve when you stop drinking. Your ability to walk and speak clearly return when the alcohol is out of your system. In many ways, you feel like you are back to normal — except for the potential hangover.

Long-Term Effects of Alcohol on the Brain

The short-term effects of alcohol on the brain seem to resolve, and in most cases, your brain can repair any damage that was done. Long-term alcohol abuse, however, compounds the damage to your brain and have deeper and longer lasting effects.
The long-term effects of alcohol on the brain involve three important neurotransmitters:

• Dopamine - This is an important feel-good chemical your brain produces naturally. Alcohol consumption causes your brain to release more dopamine to create that euphoric feeling. You also develop a craving for dopamine, and your brain knows you get it from drinking alcohol. That is how addiction develops. The long-term effect is your brain turns down its natural production of dopamine, so you only get that good feeling when drinking alcohol. When not under the influence, you may experience depression, delusions, aggression, muscle spasms and hallucinations.
• GABA - Alcohol increases the amount of this neurotransmitter in your brain which gives you that sedated feeling. Long-term effects of high GABA levels can include shortness of breath, rapid heart rate, high blood pressure, and night terrors.
• Endorphins - These natural chemicals help you tolerate pain and can create a euphoric effect. Alcohol consumption increases your brain’s release of endorphins. The long-term effects of high endorphin levels can include low sex drive, depression, infertility, and extreme fatigue.

The long-term effects of alcohol on the brain can be healed in some cases when the addiction is ended. The brain’s ability to heal itself from alcohol damage depends on the length of the addiction, the amount of alcohol consumed, other health conditions, and a number of other factors.

Brain Damage From Alcohol Abuse

Alcohol is addictive because it gets into the pleasure centers of your brain and affects your behavior. It uses the part of your brain that naturally develops habits to create a habit of seeking pleasure through alcohol consumption.
The long-term effects of alcohol on your brain can be debilitating and greatly diminish your quality of life. When you stop using alcohol, your brain has a chance to heal and develop healthier habits for creating euphoria. Addiction cannot be overcome without professional help, though.
If you or someone you love is struggling with addiction, contact Brookhaven Retreat today for help.

To find out if your symptoms point to alcohol addiction, take our Alcohol Addiction Self-Test.

Last modified on Thursday, 17 August 2017 12:27

Published in Brookhaven Blog

Tagged under

• Addiction
• Alcohol Abuse

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• How to Stop Enabling Someone Without Abandoning Them
• How Alcohol Can Affect Your Weight
• Prescription Drug Abuse: Common Causes, Symptoms and Treatment
• Stress and Alcohol Consumption

Source: https://www.brookhavenretreat.com/cms/blog-22/item/3006-alcohol-abuse-affects-brain

MRI brain scan ALCOHOL’S DAMAGING EFFECTS ON THE BRAIN

Number 63                          October 2004

ALCOHOL’S DAMAGING EFFECTS ON THE BRAIN

Difficulty walking, blurred vision, slurred speech, slowed reaction times, impaired memory: Clearly, alcohol affects the brain. Some of these impairments are detectable after only one or two drinks and quickly resolve when drinking stops. On the other hand, a person who drinks heavily over a long period of time may have brain deficits that persist well after he or she achieves sobriety. Exactly how alcohol affects the brain and the likelihood of reversing the impact of heavy drinking on the brain remain hot topics in alcohol research today.
We do know that heavy drinking may have extensive and far–reaching effects on the brain, ranging from simple “slips” in memory to permanent and debilitating conditions that require lifetime custodial care. And even moderate drinking leads to short–term impairment, as shown by extensive research on the impact of drinking on driving.
A number of factors influence how and to what extent alcohol affects the brain (1), including

• how much and how often a person drinks;
• the age at which he or she first began drinking, and how long he or she has been drinking;
• the person’s age, level of education, gender, genetic background, and family history of alcoholism;
• whether he or she is at risk as a result of prenatal alcohol exposure; and
• his or her general health status.
  
  
  
  This Alcohol Alert reviews some common disorders associated with alcohol–related brain damage and the people at greatest risk for impairment. It looks at traditional as well as emerging therapies for the treatment and prevention of alcohol–related disorders and includes a brief look at the high–tech tools that are helping scientists to better understand the effects of alcohol on the brain.

BLACKOUTS AND MEMORY LAPSES

Alcohol can produce detectable impairments in memory after only a few drinks and, as the amount of alcohol increases, so does the degree of impairment. Large quantities of alcohol, especially when consumed quickly and on an empty stomach, can produce a blackout, or an interval of time for which the intoxicated person cannot recall key details of events, or even entire events.
Blackouts are much more common among social drinkers than previously assumed and should be viewed as a potential consequence of acute intoxication regardless of age or whether the drinker is clinically dependent on alcohol (2). White and colleagues (3) surveyed 772 college undergraduates about their experiences with blackouts and asked, “Have you ever awoken after a night of drinking not able to remember things that you did or places that you went?” Of the students who had ever consumed alcohol, 51 percent reported blacking out at some point in their lives, and 40 percent reported experiencing a blackout in the year before the survey. Of those who reported drinking in the 2 weeks before the survey, 9.4 percent said they blacked out during that time. The students reported learning later that they had participated in a wide range of potentially dangerous events they could not remember, including vandalism, unprotected sex, and driving.

Binge Drinking and Blackouts

• Drinkers who experience blackouts typically drink too much and too quickly, which causes their blood alcohol levels to rise very rapidly. College students may be at particular risk for experiencing a blackout, as an alarming number of college students engage in binge drinking. Binge drinking, for a typical adult, is defined as consuming five or more drinks in about 2 hours for men, or four or more drinks for women.

Equal numbers of men and women reported experiencing blackouts, despite the fact that the men drank significantly more often and more heavily than the women. This outcome suggests that regardless of the amount of alcohol consumption, females—a group infrequently studied in the literature on blackouts—are at greater risk than males for experiencing blackouts. A woman’s tendency to black out more easily probably results from differences in how men and women metabolize alcohol. Females also may be more susceptible than males to milder forms of alcohol–induced memory impairments, even when men and women consume comparable amounts of alcohol (4).

ARE WOMEN MORE VULNERABLE TO ALCOHOL’S EFFECTS ON THE BRAIN?

Women are more vulnerable than men to many of the medical consequences of alcohol use. For example, alcoholic women develop cirrhosis (5), alcohol–induced damage of the heart muscle (i.e., cardiomyopathy) (6), and nerve damage (i.e., peripheral neuropathy) (7) after fewer years of heavy drinking than do alcoholic men. Studies comparing men and women’s sensitivity to alcohol–induced brain damage, however, have not been as conclusive.
Using imaging with computerized tomography, two studies (8,9) compared brain shrinkage, a common indicator of brain damage, in alcoholic men and women and reported that male and female alcoholics both showed significantly greater brain shrinkage than control subjects. Studies also showed that both men and women have similar learning and memory problems as a result of heavy drinking (10). The difference is that alcoholic women reported that they had been drinking excessively for only about half as long as the alcoholic men in these studies. This indicates that women’s brains, like their other organs, are more vulnerable to alcohol–induced damage than men’s (11).
Yet other studies have not shown such definitive findings. In fact, two reports appearing side by side in the American Journal of Psychiatry contradicted each other on the question of gender–related vulnerability to brain shrinkage in alcoholism (12,13). Clearly, more research is needed on this topic, especially because alcoholic women have received less research attention than alcoholic men despite good evidence that women may be particularly vulnerable to alcohol’s effects on many key organ systems.

BRAIN DAMAGE FROM OTHER CAUSES

People who have been drinking large amounts of alcohol for long periods of time run the risk of developing serious and persistent changes in the brain. Damage may be a result of the direct effects of alcohol on the brain or may result indirectly, from a poor general health status or from severe liver disease.
For example, thiamine deficiency is a common occurrence in people with alcoholism and results from poor overall nutrition. Thiamine, also known as vitamin B1, is an essential nutrient required by all tissues, including the brain. Thiamine is found in foods such as meat and poultry; whole grain cereals; nuts; and dried beans, peas, and soybeans. Many foods in the United States commonly are fortified with thiamine, including breads and cereals. As a result, most people consume sufficient amounts of thiamine in their diets. The typical intake for most Americans is 2 mg/day; the Recommended Daily Allowance is 1.2 mg/day for men and 1.1 mg/day for women (14).

Wernicke–Korsakoff Syndrome

Up to 80 percent of alcoholics, however, have a deficiency in thiamine (15), and some of these people will go on to develop serious brain disorders such as Wernicke–Korsakoff syndrome (WKS) (16). WKS is a disease that consists of two separate syndromes, a short–lived and severe condition called Wernicke’s encephalopathy and a long–lasting and debilitating condition known as Korsakoff’s psychosis.
The symptoms of Wernicke’s encephalopathy include mental confusion, paralysis of the nerves that move the eyes (i.e., oculomotor disturbances), and difficulty with muscle coordination. For example, patients with Wernicke’s encephalopathy may be too confused to find their way out of a room or may not even be able to walk. Many Wernicke’s encephalopathy patients, however, do not exhibit all three of these signs and symptoms, and clinicians working with alcoholics must be aware that this disorder may be present even if the patient shows only one or two of them. In fact, studies performed after death indicate that many cases of thiamine deficiency–related encephalopathy may not be diagnosed in life because not all the “classic” signs and symptoms were present or recognized.

Human Brain

Schematic drawing of the human brain, showing regions vulnerable to alcoholism-related abnormalities.

Approximately 80 to 90 percent of alcoholics with Wernicke’s encephalopathy also develop Korsakoff’s psychosis, a chronic and debilitating syndrome characterized by persistent learning and memory problems. Patients with Korsakoff’s psychosis are forgetful and quickly frustrated and have difficulty with walking and coordination (17). Although these patients have problems remembering old information (i.e., retrograde amnesia), it is their difficulty in “laying down” new information (i.e., anterograde amnesia) that is the most striking. For example, these patients can discuss in detail an event in their lives, but an hour later might not remember ever having the conversation.
Treatment

The cerebellum, an area of the brain responsible for coordinating movement and perhaps even some forms of learning, appears to be particularly sensitive to the effects of thiamine deficiency and is the region most frequently damaged in association with chronic alcohol consumption. Administering thiamine helps to improve brain function, especially in patients in the early stages of WKS. When damage to the brain is more severe, the course of care shifts from treatment to providing support to the patient and his or her family (18). Custodial care may be necessary for the 25 percent of patients who have permanent brain damage and significant loss of cognitive skills (19).
Scientists believe that a genetic variation could be one explanation for why only some alcoholics with thiamine deficiency go on to develop severe conditions such as WKS, but additional studies are necessary to clarify how genetic variants might cause some people to be more vulnerable to WKS than others.

LIVER DISEASE

Most people realize that heavy, long–term drinking can damage the liver, the organ chiefly responsible for breaking down alcohol into harmless byproducts and clearing it from the body. But people may not be aware that prolonged liver dysfunction, such as liver cirrhosis resulting from excessive alcohol consumption, can harm the brain, leading to a serious and potentially fatal brain disorder known as hepatic encephalopathy (20).
Hepatic encephalopathy can cause changes in sleep patterns, mood, and personality; psychiatric conditions such as anxiety and depression; severe cognitive effects such as shortened attention span; and problems with coordination such as a flapping or shaking of the hands (called asterixis). In the most serious cases, patients may slip into a coma (i.e., hepatic coma), which can be fatal.
New imaging techniques have enabled researchers to study specific brain regions in patients with alcoholic liver disease, giving them a better understanding of how hepatic encephalopathy develops. These studies have confirmed that at least two toxic substances, ammonia and manganese, have a role in the development of hepatic encephalopathy. Alcohol–damaged liver cells allow excess amounts of these harmful byproducts to enter the brain, thus harming brain cells.
Treatment

Physicians typically use the following strategies to prevent or treat the development of hepatic encephalopathy.

• Treatment that lowers blood ammonia concentrations, such as administering L–ornithine L–aspartate.
• Techniques such as liver–assist devices, or “artificial livers,” that clear the patients’ blood of harmful toxins. In initial studies, patients using these devices showed lower amounts of ammonia circulating in their blood, and their encephalopathy became less severe (21).
• Liver transplantation, an approach that is widely used in alcoholic cirrhotic patients with severe (i.e., end–stage) chronic liver failure. In general, implantation of a new liver results in significant improvements in cognitive function in these patients (22) and lowers their levels of ammonia and manganese (23).

ALCOHOL AND THE DEVELOPING BRAIN

Drinking during pregnancy can lead to a range of physical, learning, and behavioral effects in the developing brain, the most serious of which is a collection of symptoms known as fetal alcohol syndrome (FAS). Children with FAS may have distinct facial features (see illustration). FAS infants also are markedly smaller than average. Their brains may have less volume (i.e., microencephaly). And they may have fewer numbers of brain cells (i.e., neurons) or fewer neurons that are able to function correctly, leading to long–term problems in learning and behavior.

Fetal Alcohol Syndrome

Children with fetal alcohol syndrome (FAS) may have distinct facial features.

Treatment

Scientists are investigating the use of complex motor training and medications to prevent or reverse the alcohol–related brain damage found in people prenatally exposed to alcohol (24). In a study using rats, Klintsova and colleagues (25) used an obstacle course to teach complex motor skills, and this skills training led to a re–organization in the adult rats’ brains (i.e., cerebellum), enabling them to overcome the effects of the prenatal alcohol exposure. These findings have important therapeutic implications, suggesting that complex rehabilitative motor training can improve motor performance of children, or even adults, with FAS.
Scientists also are looking at the possibility of developing medications that can help alleviate or prevent brain damage, such as that associated with FAS. Studies using animals have yielded encouraging results for treatments using antioxidant therapy and vitamin E. Other preventive therapies showing promise in animal studies include 1–octanol, which ironically is an alcohol itself. Treatment with l–octanol significantly reduced the severity of alcohol’s effects on developing mouse embryos (26). Two molecules associated with normal development (i.e., NAP and SAL) have been found to protect nerve cells against a variety of toxins in much the same way that octanol does (27). And a compound (MK–801) that blocks a key brain chemical associated with alcohol withdrawal (i.e., glutamate) also is being studied. MK–801 reversed a specific learning impairment that resulted from early postnatal alcohol exposure (28).
Though these compounds were effective in animals, the positive results cited here may or may not translate to humans. Not drinking during pregnancy is the best form of prevention; FAS remains the leading preventable birth defect in the United States today.

GROWING NEW BRAIN CELLS

For decades scientists believed that the number of nerve cells in the adult brain was fixed early in life. If brain damage occurred, then, the best way to treat it was by strengthening the existing neurons, as new ones could not be added. In the 1960s, however, researchers found that new neurons are indeed generated in adulthood—a process called neurogenesis (29). These new cells originate from stem cells, which are cells that can divide indefinitely, renew themselves, and give rise to a variety of cell types. The discovery of brain stem cells and adult neurogenesis provides a new way of approaching the problem of alcohol–related changes in the brain and may lead to a clearer understanding of how best to treat and cure alcoholism (30).
For example, studies with animals show that high doses of alcohol lead to a disruption in the growth of new brain cells; scientists believe it may be this lack of new growth that results in the long–term deficits found in key areas of the brain (such as hippocampal structure and function) (31,32). Understanding how alcohol interacts with brain stem cells and what happens to these cells in alcoholics is the first step in establishing whether the use of stem cell therapies is an option for treatment (33).

SUMMARY

Alcoholics are not all alike. They experience different degrees of impairment, and the disease has different origins for different people. Consequently, researchers have not found conclusive evidence that any one variable is solely responsible for the brain deficits found in alcoholics. Characterizing what makes some alcoholics vulnerable to brain damage whereas others are not remains the subject of active research (34).
The good news is that most alcoholics with cognitive impairment show at least some improvement in brain structure and functioning within a year of abstinence, though some people take much longer (35–37). Clinicians must consider a variety of treatment methods to help people stop drinking and to recover from alcohol–related brain impairments, and tailor these treatments to the individual patient.
Advanced technology will have an important role in developing these therapies. Clinicians can use brain–imaging techniques to monitor the course and success of treatment, because imaging can reveal structural, functional, and biochemical changes in living patients over time. Promising new medications also are in the early stages of development, as researchers strive to design therapies that can help prevent alcohol’s harmful effects and promote the growth of new brain cells to take the place of those that have been damaged by alcohol.

SIDEBAR Using High–Tech Tools to Assess Alcoholic Brain Damage Researchers studying the effects of alcohol use on the brain are aided by advanced technology such as magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), positron emission tomography (PET), and electrophysiological brain mapping. These tools are providing valuable insight into how alcohol affects the brain’s structure and function. Long–term heavy drinking may lead to shrinking of the brain and deficiencies in the fibers (white matter) that carry information between brain cells (gray matter). MRI and DTI are being used together to assess the brains of patients when they first stop chronic heavy drinking and again after long periods of sobriety, to monitor for possible relapse to drinking (38). Memory formation and retrieval are highly influenced by factors such as attention and motivation (39). Studies using MRI are helping scientists to determine how memory and attention improve with long-time abstinence from alcohol, as well as what changes take place when a patient begins drinking again. The goal of these studies is to determine which alcohol–induced effects on the brain are permanent and which ones can be reversed with abstinence. PET imaging is allowing researchers to visualize, in the living brain, the damage that results from heavy alcohol consumption (40). This “snapshot” of the brain’s function enables scientists to analyze alcohol’s effects on various nerve cell communication systems (i.e., neurotransmitter systems) as well as on brain cell metabolism and blood flow within the brain. These studies have detected deficits in alcoholics, particularly in the frontal lobes, which are responsible for numerous functions associated with learning and memory, as well as in the cerebellum, which controls movement and coordination. PET also is a promising tool for monitoring the effects of alcoholism treatment and abstinence on damaged portions of the brain and may help in developing new medications to correct the chemical deficits found in the brains of people with alcohol dependence. Another high–tech tool, electroencephalography (EEG), records the brain’s electrical signals (41). Small electrodes are placed on the scalp to detect this electrical activity, which then is magnified and graphed as brain waves (i.e., neural oscillations). These brain waves show real–time activity as it happens in the brain. Many male alcoholics have a distinctive electrophysiological profile—that is, a low amplitude of their P3 components (see figure). P3 amplitudes in women alcoholics also are reduced, although to a lesser extent than in men. For many years it was assumed that the P3 deficit observed in alcoholics was the result of alcohol’s damage to the brain. Then it was determined that while many of the clinical symptoms and electrophysiological measures associated with alcoholism return to normal after abstinence, the P3 amplitude abnormality persists (42). The P3 component is reduced in alcoholics compared with control subjects. This continued deficit in long–term abstinent alcoholics suggests that P3 deficits may be a marker of risk for alcohol dependence, rather than a result of alcohol use. In fact, a number of studies have since reported low P3 amplitudes in young people who have not started drinking alcohol but who are at high risk for developing alcoholism, such as young sons of alcoholic fathers (43,44). Markers such as the P3 can help identify people who may be at greatest risk for developing problems with alcohol.

END OF SIDEBAR

References

 https://pubs.niaaa.nih.gov/publications/aa63/aa63.pdf

Source material for this Alcohol Alert originally appeared in the journal Alcohol Research & Health, “Alcoholic Brain Damage” (Vol. 27, No. 2, 2003). 

Alcohol Research & Health is the quarterly, peer–reviewed journal published by the National Institute on Alcohol Abuse and Alcoholism. 

Each issue of AR&H provides in–depth focus on a single topic in the field of alcohol research.


Back issues of Alcohol Research & Health and additional resources can be downloaded from

 NIAAA’s Web site, www.niaaa.nih.gov.

Subscriptions are available from the Superintendent of Documents for $25. Write to New Orders, Superintendent of Documents, P.O. Box 371954, Pittsburgh, PA 15250–7954; or fax 202/512–2250.

U.S.

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HEALTH AND HUMAN SERVICES

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Source: https://pubs.niaaa.nih.gov/publications/aa63/aa63.htm